Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Invited Review



Oxidative damage and brain atrophy in alcoholics

Emilio Gonzalez-Reimers, Geraldine Quintero-Platt, Camino Fernandez-Rodriguez, Emilio Gonzalez-Arnay, Candelaria Martin-Gonzalez, Onan Perez-Hernandez.

Abstract
Generalized brain atrophy, especially affecting frontal lobes, hippocampus and cerebellum, is frequently observed in alcoholics. This alteration leads to cognitive dysfunction (that may affect 50-80% of alcoholics, even young people) and altered gait and movement disorders.
Although several factors may contribute, oxidative damage, mainly due to increased production of reactive oxygen species plays an outstanding role in its pathogenesis, and will be reviewed in this manuscript. Among them, we can consider mechanisms directly dependent on ethanol metabolism; mechanisms related to increased cytokine secretion, partly dependent on ethanol-induced increased intestinal permeability, endotoxemia and micro RNA induction; mechanisms related to ethanol-mediated iron overload; mechanisms related to ethanol-derived toxic lipid synthesis; and mechanisms related to altered trace element and vitamin concentrations that can affect antioxidant systems.
Despite the role of pro-oxidants, and in contrast with experimental data, no clear-cut benefit has been observed in clinical trials with antioxidants. Alcohol abstinence, together with adequate nutrition, still constitute the most effective therapeutic approach in these patients.

Key words: Encephalopathy, ethanol brain atrophy, cytokines, liver-brain axis, Wernicke´s gut-brain axis


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»Effect of Nigella sativa extract on some physiological parameters and histological changes in alloxan-induced diabetic albino rats
»Association of duration of illness and compliance with stress levels in type 2 diabetes mellitus patients – A pilot study
»Towards TRAIL to silencing of SMURF and NEDD4: FLIP is flopped
»Psychiatric Aspects of Obesity, Behavior and Cognitive Behavior Therapy in Treatment
»Neurological side effects of lithium
»Opuntia elatior Mill.(Nagaphani): A Review on its Ethnobotany,Phytochemical and Pharmacological Properties
»Fast disintegrating tablets of amiodarone for intra-oral administration
»Clinical Characteristics of Aerobic Vaginitis and Its Association to Vaginal Candidiasis, Trichomonas Vaginitis and Bacterial Vaginosis
»Characteristics of Rotavirus Diarrhea in Hospitalized Children in Kosovo
»Radical cystoprostatectomy and ileal neobladder substitution: an experience with a T2 invasive bladder tumor patient
»Atipically located pyoderma gangrenosum worsen surgical debridement: case report



Advertisement
Archives of Clinical and Experimental Surgery (ACES)

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.