Abstract

The increase in ApoB levels, atherogenic index of plasma (AIP) and castelli risk index I-II (CRI) is prediction of cardiovascular disease in metabolic syndrome. Lipid peroxidation could initiate the process of atherosclerosis and involved in the etiology of cardiovascular disease. Dietary fish oil and extract of Curcuma has been shown to beneficially reducing effect of atherosclerosis and lipid peroxidation. The aim of this study was to determine the effect of Catfish Oil and Curcuma longa Linn extract on ApoB levels and lipid ratios as protective nutraceutical for metabolic syndrome. Thirty male Wistar rats were randomly divided into 5 groups namely HC (healthy control), HFFD (High-Fat High-Fructose Diet), and intervention group P1 (High-Fat High-Fructose Diet + Catfish Oil 0.08 ml/gr/day), P2 (High-Fat High-Fructose Diet + Curcuma longa linn extract 5.04 mg/gr/day), and P3 with High-Fat High-Fructose Diet + combination of both. HFFD was used to induced metabolic syndrome. ApoB levels were measured by the Immunoturbidimetric and lipid levels with ELISA method. Lipid ratios was calculated by AIP (log TG/HDL), and the CRI I-II (TC/HDL,LDL/HDL). The study was showed significantly reduced (p=

Key words: Catfish oil, Curcuma longa Linn, AIP, CRI I-II, Metabolic Syndrome