Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Research

Egypt. J. Exp. Biol. (Zoo.). 2007; 3(0): 229-239


Iman Zakaria.

Glucocorticoids have great clinical importance as anti-inflammatory drugs. Dexamethasone, a long acting synthetic steroid, was used in the present study to investigate its effect chronically and acutely on the retina of adult pregnant mice and their newborns. Pregnant mice were divided into three control groups and three experimental ones. The pregnant mice of the first experimental group were treated by a daily subcutaneous therapeutic dose of 0.02 mg dexamethasone from the 1st to the 21st day of gestation (chronic). The pregnant mice of the second experimental group were given the same dose of dexamethasone from the 7th day to the 14th day of gestation (acute), while the pregnant mice of the third group were given the same dose of the drug from the 14th day to the 21st day of gestation (acute). At the end of treatment, the retina of the adults of the first group, retina of the adults and newly born mice of the second and third groups were dissected and prepared for microscopical examination. The thickness of the whole retinal layers has decreased in the adult following dexamethasone administration and was time dependent, while the retinal tissue of the newly born mice showed an increase in thickness. Electron microscopic examination of adult and newborns revealed vacuolation of the pigmented epithelial cells. In the adults, the outer segments of the photoreceptors revealed extensive disorganization and degeneration. Degenerated cytoplasmic areas in the outer nuclear layer cells were seen. Moreover, swollen and vacuolated mitochondria were also observed in the cytoplasm of the inner nuclear layer cells. Nuclear membrane detachment was detected in the outer nuclear layer of the newborns. However, the ganglionic cells in the adult and newborn retinas were intact. In conclusion, this study revealed that prolonged administration of dexamethasone, obviously affects the retinal tissue of both pregnant and newly born mice and visual dysfunction may be expected

Key words: Dexamethasone, Retina, Pregnant Mice, Newly Born

Full-text options

Full-text Article

American Journal of Diagnostic Imaging


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.