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Egypt. J. Exp. Biol. (Zoo.). 2007; 3(0): 127-133


AMELIORATIVE ROLE OF SILYMARIN AGAINST RIBAVIRIN INDUCED TOXICITY IN THE KIDNEY OF ALBINO RAT

Sabah F El-Abd, Yosry Okda.

Abstract
Ribavirin is the first anti-C and other virus drug all over the world. Silymarin is one of the hepatoprotective drugs that belong to the group of free-radical scavengers. The present work was planned to investigate the histo-pathological, histochemical and biochemical effects of ribavirin on the kidney of albino rats. Treating animals with prescribed dose of ribavirin (12mg/kg body weight in bi-distilled water twice a day) for one, two and three weeks induced many histopathological, histochemical and biochemical changes in the kidney. After two weeks of treatment with ribavirin, the blood vessels were congested with atrophy of kidney glomeruli, degeneration of renal tubules and depletion of glycogen and total protein contents in the kidney tissues. Intraperitoneal injection of silymarin simultaneous with ribavirin at a dose level (250 mg/ kg body weight in bi-distilled water twice a day) for one, two and three weeks reduced the histopathological, histochemical, and biochemical lesions that induced by ribavirin. In conclusion, the present study showed that ribavirin affects the structure and function of the kidney, whereas silymarin had a protective effect.

Key words: Ribavirin- Silymarin- Kidney- Pathology- Histochemistry- Biochemistry.



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