Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2015; 5(8): 034-041

Ability of scavenging free radicals and preventing lipid peroxidation of some phenols and ascorbic acid

Jaqueline Badanai, Celi Silva, Denise Martins, Dulce Antunes, Maria Graça Miguel.

The capacity for scavenging free radicals and preventing lipid peroxidation of gallic, caffeic, and p-coumaric acids, thymol, eugenol and ascorbic acid were evaluated. The capacity for scavenging DPPH• free radicals were performed in ethanol 96% and ethanol 70%. In the same assay, the activity estimation was followed at 10, 20 and 30 minutes. In this assay, eugenol presented the best activity (IC50 ranging from 2.10 mg/mL to 9.74 mg/mL. In the opposite site, p-coumaric had the lowest activity, in which the IC50 values were not possible to determine. Generally, 10 minutes of reaction provided lower scavenging activities than 30 minutes. The sole exception was ascorbic acid in which the activities were independent on the time of reaction. Ascorbic acid, eugenol and thymol possessed higher ability for scavenging DPPH free radicals in ethanol 70% than in ethanol 96%.
Gallic and p-coumaric acids as well as thymol revealed to be the best scavengers of ABTS•+ free radicals in contrast to ascorbic acid. The capacity for preventing lipid peroxidation was dependent on the concentration of samples. The assay showed that higher concentrations of gallic acid, thymol and p-coumaric acid added to sunflower oil (from 0.3 to 0.6%) induced higher lipid peroxidation with higher peroxide values. In contrast, increasing the percentages of caffeic acid and eugenol induced lower peroxidation of the sunflower oil. The percentage of samples added to this fat did not influence the index of p-anisidine. In this test, gallic acid had the best capacity for preventing the formation of 2,4-dienals and 2-alkenals decadienals able to react with p-anisidine.

Key words: Phenolic acids; eugenol; thymol; ascorbic acid; antioxidant

Similar Articles

Efficient production of oligomeric chitin with narrow distributions of degree of polymerization using sonication-assisted phosphoric acid hydrolysis.
Zhang X, Mao Y, Briber RM
Carbohydrate polymers. 2022; 276(): 118736

Study on the antioxidative mechanism of tocopherol loaded ethyl cellulose particles in thermal-oxidized soybean oil.
Liu Y, Ma X, Li J, Fan L, Huang S
Carbohydrate polymers. 2022; 276(): 118734

Overcoming the limitations of COVID-19 diagnostics with nanostructures, nucleic acid engineering, and additive manufacturing.
Li N, Zhao B, Stavins R, Peinetti AS, Chauhan N, Bashir R, Cunningham BT, King WP, Lu Y, Wang X, Valera E
Current opinion in solid state & materials science. 2022; 26(1): 100966

Electrochemically derived nanographene oxide activates endothelial tip cells and promotes angiogenesis by binding endogenous lysophosphatidic acid.
Liu W, Luo H, Wei Q, Liu J, Wu J, Zhang Y, Chen L, Ren W, Shao L
Bioactive materials. 2022; 9(): 92-104

Inulin as a functional ingredient and their applications in meat products.
Illippangama AU, Jayasena DD, Jo C, Mudannayake DC
Carbohydrate polymers. 2022; 275(): 118706

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites