The combined viral hepatitis and schistose-miasis incidence was found to be increasing; however scarce studies are available which investigated the influence of Schistosoma mansoni on the HCV specific immune respo-nse. This study included four groups: Group 1 included 23 patients infected with chronic HCV, Group 2 included 10 patients infected with Schistosoma mansoni, Group 3 included 21 patients infected with chronic HCV and Schistosoma mansoni, Group 4 included 10 healthy controls. HCV-specific CD4+ and CD8+ T cell responses were measured by flow cytometery in all groups and correlated with PCR level. The infected patients with chronic HCV alone had stronger CD4+ T cell response than did coinfected patients also the coinfected patients had the lowest percent of CD8+ T cell, and significantly higher HCV-RNA titers. An inverse relationship between virus load and CD4+ T cell responses were found. Schistosomiasis is one of the mechanisms which lead to viral persistence through down regulation of immune response and accelerate liver damage in HCV patients.
Schistosoma mansoni, CD4+, CD8+ T cell, HCV