Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research

Egypt. J. Exp. Biol. (Zoo.). 2010; 6(1): 117-127


EFFECT OF GREEN TEA EXTRACT ON THE APOPTOTIC AND ANTI-ANGIOGENIC PHENOMENA IN PERIPHERAL BLOOD OF BREAST CANCER PATIENTS

Safia M. Hassan Ashour A. Abdel Mawla Sameh IH. Zaki Atef AA. Abd El-All.

Abstract
Green tea is natural dried leaves of the tea plant, Camellia sinensis. Green tea extract is bioflavonoid-rich compound, with several phenol groups. The dominant polyphynol (catechin) in green tea is epigallocatechin gallate (EGCG) which is a potent antioxidant. In the case of breast cancer, catechins were in fact shown to interfere with the binding of estrogen to estrogen receptors. This study evaluated the green tea extract effect on breast cancer patients using morphological and immunocytochemical techniques. It included 3 groups, 2 treated groups and one control group. Chemotherapy for 6 cycles was administered plus 1000mg green tea extract /day or alone. Blood smears were applied from both control and treated groups either preradicalmastectomy, or post 3 and 6 cycles of treatment. Apoptotic and antiangiogenic effects were revealed through Leishman’s stain and immunocytochemical technique of both vascular endothelial growth factor (VEGF) and nuclear factor kappa B (NFkB). Morphological results using Leishman’s stain illustrated that the apoptosis in blood smears of women administered with green tea extract was more prominent than that of their corresponding without green tea extract administration or of control women. Immunocytochemical findings showed that there was a decrease in VEGF & NFkB in women administered green tea extract as compared with their partners of control group as well as those treated with chemotherapy alone. In conclusion, green tea played a dual role in decreasing the angiogenesis while it increased apoptosis. This revealed that green tea as adjuvant therapy showed a positive effect.

Key words: Human breast cancer, Green tea, immunocytochemistry, VEGF, NF-kB



Similar Articles

Biovalue in Human Brain Banking: Applications and Challenges for Research in Neurodegenerative Diseases.
Vedam-Mai V
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 209-220

Generating Monocyte-Derived Endothelial-like Cells for Vascular Regeneration.
Smith RJ, Andreadis ST
Methods in molecular biology (Clifton, N.J.). 2022; 2375(): 13-19

Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling.
Bertucci T, Kakarla S, Kim D, Dai G
Methods in molecular biology (Clifton, N.J.). 2022; 2375(): 1-12

Identifying Neural Progenitor Cells in the Adult Human Brain.
Park TIH, Waldvogel HJ, Montgomery JM, Mee EW, Bergin PS, Faull RLM, Dragunow M, Curtis MA
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 125-154

Isolation and Culture of Precursor Cells from the Adult Human Spinal Cord.
Bauchet L, Poulen G, Lonjon N, Vachiery-Lahaye F, Bourinet E, Perrin FE, Hugnot JP
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 103-110


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites