Abstract

The current study tended to search the impact of beta-carotene and anti-inflammatory Triamcinolone acetonide (TA) drug on the immune system in male mice (Balb / C). It was taken into account for this study to do it through two stages of the life stages of mice; the first stage was before the mice reach adulthood, so the transaction began at the age of four weeks. The second phase was after the arrival of mice the adulthood age where the transaction began at the age of eight weeks. In an attempt to reduce the possible side effects of the TA drug, which is an immunological inhibitor, beta carotene has been used as a natural substance assumed to be immunocompetent. Therefore, the mice were treated with the drug alone and the others with both beta-carotene and the drug concurrently. The study stated and summarized the positive effect of beta-carotene and the drug treatment on surface marker Thy 1.2+and PNA+ in lymphocytes of thymus gland. The negative effect of treated with the drug alone compared with control group. Thus, the present research aimed at trying to help the injecting of the anti-inflammatory Triamcinolone acetonide (TA) drug that contain a derivative of cortisone to alleviate it’s side effects through using beta-carotene during the treatment period.

Key words: Triamcinolone Acetonide, Lymphocytes, Beta-Carotene