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Original Article

J. Islam. Int. Med. Coll.. 2015; 10(3): 214-218

Comparison of Aqueous and Ethanolic Extract of Syzygium Aromaticum on Blood Glucose in Diabetic Rats

Zunnera Rashid Chaudhry, Asif Naseer, Erum Rasheed Chaudhry, Sana Rasheed Chaudhry.

Objective: To compare the effect of 50% Aqueous and 50% Ethanolic extract of Syzygium aromaticum on blood glucose
level in STZ induced diabetic rats in comparison with insulin.
Study Design: Randomized control trial.
Place and Duration of Study: This study was conducted at National Institute of Health Islamabad from July 2011 to
December 2011.
Materials and Methods: Forty adult rats of Sprague dawaley specie were equally divided into 5 groups (I‐V). Group‐ I
control. Group (II‐V) received a single intraperitoneal injection of STZ and rats having fasting blood glucose above
200mg/dl were selected. Group‐II served as diabetic control , group III received 50% aqueous extract at a dose of 750
mg/kg body weight for sixty days and group 1Vrats received 50% ethanolic extract of Syzygium aromaticum at a dose of
750 mg/kg body weight for sixty days. Group V (standard) received the dose of 0.6 units/kg body weight of humulin insulin
70/30 subcutaneously bid for sixty days. After giving the injection of STZ fasting blood samples were taken at zero 15, 30
and 60 days and comparison is done between the glucose lowering effect of aqueous and ethanolic extract of Syzygium
Results: The 50% ethanolic extract of Syzygium aromaticum showed more reduction in blood glucose level than the 50%
aqueous extract of Syzygium aromaticum. The levels of blood glucose markedly decreased in group‐1V receiving 750
mg/kg body of ethanolic extract as compared to group III receiving the same dose of aqueous extract. Group V receiving
insulin showed the level of this parameter almost closer to the blood glucose levels of group III rats.
Conclusion: The reduction in blood glucose with 750 mg/kg body weight of ethanolic extract of Syzygium aromaticum is
more than with aqueous extract and insulin.

Key words: Syzygium Aromaticum Extract, Diabetes Mellitus, Glucose Lowering Effect.

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