The present study investigated the cytogenetic and testicular damage induced by concor drug (0.9 mg / kg bodyweight) for five weeks and the protective role of grapefruit juice (27 mg/kg bodyweight). Animals given concor demonstrated a significant increase in the percentage of chromosomal aberrations either structural or numerical and decrease the mitotic index. Besides, animals administered concor showed DNA damage appeared in the single strand breaks (comet assay). Testis of concor-treated rats exhibited many histopathological and morphometric alterations. In addition, the number of sperm head abnormalities was increased. Treating animals with concor and grapefruit juice led to an improvement in chromosomal aberrations, mitotic index, DNA damage and testicular alterations caused by concor. In conclusion, the results of this study indicated that grapefruit juice showed a protective effect on cytotoxicty and testicular alterations induced by concor in albino rats and this may be due to its potent antioxidant effects.
Key words: Concor, Grapefruit, Chromosomes, Comet assay, Testis
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