In this study the ability of three anti-depression drugs (Risperdal, Cymbalta, and Faverin) to induce genetic changes in Saccharomyces cerevisiae D7 was studied, as well as the effects of these drugs on survival rates of S. cerevisiae D7. The results revealed that the survival percentage of Saccharomyces cerevisiae D7 strain was decreased with increase of concentration and exposure period to anti-depression drugs. On the other hand, the Risperdal, Cymbalta, and Faverin are capable of inducing mitotic gene conversion, reversion, and mitotic crossing over. The high doses of drugs resulted in increasing in the average of cells recombination compared with the control sample. The high concentration of Risperdal (0.012 mg/ml) induced high level of mutagenic activity (2.2) compared with reversion and mitotic crossing over which recorded some repeated values (2.3 & 2.5, respectively) compared with control. According to the two other concentrations (0.002 and 0.006 mg/ml), there was nothing mentioned about the active level of the drug with the control towards the three end points. The high concentration of cymbalta (0.18 mg/ml) induced the high level of mutagenic activity (3.04) compared with reversion and crossing over which indicated some repeated values (2.98 & 3.88, respectively) compared with control, while at concentration of (0.12 mg/ml) induced mutagenic activity, reversion, and crossing over (1.88, 2.47, and 2.41, respectively), compared with control. Faverin was capable of inducing gene conversion, reverse mutation and mitotic crossing over at high concentration (0.4 and 0.3 mg/ml, respectively), in the lowest concentration it did not exceed (0.2 mg/ml) inducing gene conversion, reverse mutation and mitotic crossing over. Therefore, the application of these chemicals should be carried out under certain cases of necessity.
Key words: Anti-depression drugs- Genetics changes-mitotic gene conversation-mutation- Saccharomyces cerevisiae
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