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Original Article

J App Pharm Sci. 2015; 5(Supplement 2): 062-066

Immunomodulatory Effect of Water Extract of Stachytarpheta jamaicensis (L.) Vahl

Suci Nar Vikasari, AndreanusAndaja Soemardji, Afifah Bambang Sutjiatmo, Suryani.

Stachytarpheta jamaicensis (L) Vahl traditionally is used to treat several diseases. The objective of this study is to test immunomodulatory effect of water extract of S. jamaicensis (L.) Vahl. herbs. Immunomodulatory assay of water extract of S. jamaicensis herbs have been examined in male Balb/c mice using carbon clearance assay. The doses of the extract were 62.5, 125, and 250 mg/kg bw. Parameter of immunomodulatory effect was phagocytic indexes after seven days administration of the extract. The result showed that water extract of S. jamaicensis at dose of 62.5 and 250 mg/kg bw had lower phagocytic index compared to Zymosan A as immunostimulant, but higher phagocytic indexes compared to Methylprednisolone as immunosuprresant. It can be concluded that water extract of S. jamaicensis had ability as immunosuppresant.

Key words: Stachytarpheta jamaicensis (L) Vahl , immunomodulatory, carbon clearance, phagocytic index

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