Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Med-Science. 2012; 1(1): 1-12

Effects of Cigarette Smoke on Tissue Trace Element Concentration of Rats Exposed to Second-hand Smoke

Kivanc Ergen, Furuzan Yildiz, Mustafa Ozcan, Mustafa Cekmen, Pelin Tanyeri, Tijen Utkan, Yunus Karakoc.

Trace elements have an important effect on and play a key role in a variety of the processes necessary for life. Studies have indicated a definite correlation between content of trace elements and many common diseases. It has been concluded that smoking may be a substantial source of intake of these hazardous elements, not only to the smoker, but to nonsmokers via passive smoke, as well. Even passive intake of such elements can change the metabolism of other trace elements and influence their concentrations. In order to assess their potential role in some human diseases, it is necessary to measure trace element concentrations in various tissues in experimental models. In this study, liver, kidney and spleen tissue samples from rats exposed to secondhand smoke were analysed for Fe, Cu, Zn, Cr, Mn and Co trace element levels by atomic absorption spectrophotometer. Cr, Mn, Fe and Co levels in the liver, Fe and Co levels in the kidney, and Zn, Cu, Mn and Co levels in the spleen were significantly lower than those of controls, but Cu levels in the kidney and Fe levels in the spleen were significantly higher than those of controls. Our data suggest that chronic exposure to cigarette smoke alters the trace element concentration of various tissues in rats exposed to secondhand smoke. These alterations may be attributable to oxidative stress produced by cumulative effect of inhaled smoke rather than the toxic effect of absorbed toxic metals. Low Mn levels in the liver and spleen, increased Cu levels in kidney and Fe levels in the spleen, and changes in the metabolism of Zn, Fe and Cu may be indicators of oxidative stress. Decreases in Co and Cr levels in rats exposed to secondhand smoke may also be related to the intake of the toxic trace elements present in cigarette smoke.

Key words: toxic elements, trace elements, cigarette smoke, oxygen free radical, oxidative stress

Similar Articles

Dissecting lipid droplet biology with coherent Raman scattering microscopy.
Chen T, Yavuz A, Wang MC
Journal of cell science. 2022; 135(5):

Effects of hydrogen water treatment on antioxidant system of litchi fruit during the pericarp browning.
Yun Z, Gao H, Chen X, Chen Z, Zhang Z, Li T, Qu H, Jiang Y
Food chemistry. 2021; 336(): 127618

Detoxification of Reactive Aldehydes by Alda-1 Treatment Ameliorates Experimental Autoimmune Encephalomyelitis in Mice.
Islam SMT, Won J, Kim J, Qiao F, Singh AK, Khan M, Singh I
Neuroscience. 2021; 458(): 31-42

GSK3-mediated stress signaling inhibits legume-rhizobium symbiosis by phosphorylating GmNSP1 in soybean.
He C, Gao H, Wang H, Guo Y, He M, Peng Y, Wang X
Molecular plant. 2021; 14(3): 488-502

CaO/FeO nanocomposites for oxygen-independent generation of radicals and cancer therapy.
Mamat M, Wang X, Wu L, Zhao R, Cao J, Qi X, Shen S
Colloids and surfaces. B, Biointerfaces. 2021; 204(): 111803

Full-text options

Add your Article(s) to Indexes
• CiteIndex: Articles & Statistics

American Journal of Diagnostic Imaging


Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.