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Emir. J. Food Agric. 2012; 24(2): 142-147

Cytotoxic activity in Tagetes lucida Cav. ?

Jorge A. Mejia-Barajas, Rosa E. N. Del Rio, Rosa E. Martinez-Muń oz, Alberto Flores-Garcia and
Mauro M. Martinez-Pacheco*.

Tagetes lucida (common name Santamaria) is a native herb widely used in the area with an important economicpotential. It has several uses, such as, food, antiseptic, to control diseases infectious and spirituals. The objectiveof this work was to determine the agent of the cytotoxic activity from T. lucida. 17 straw extracts from differentorgans of T. lucida were obtained by cold maceration (methanol:chloroform), successive maceration (hexane,dichloromethane and methanol), infusion and extraction Soxhlet (ethyl acetate). The mostly of the plant extractwere citotoxic to the crustacean A. salina. Hexanic extracts were notable for their cytotoxic effect. They werepurified the 7-methoxycoumarin and 6,7-dimethoxycoumarin from leaf hexanic extract and both compoundscaused citotoxicity in A. salina, with LC50 values of 28 and 238 µg/ml, respectively. We find that the cytotoxiceffect observed in T. lucida is due to the coumarins.

Key words: Citotoxicity, coumarins, T. lucida

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