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Study of serum uric acid and creatinine in hypertensive disorders of pregnancy

Sapna Vyakaranam, Aparna Varma Bhongir, Dakshayani Patlolla, Rekha Chintapally.

Background: Renal dysfunction, increased xanthine oxidase activity and oxidative stress in placenta contributes to the elevated uric acid levels in preeclampsia (PE).

Objective: To determine serum uric acid and creatinine in hypertensive disorders of pregnancy and correlate with fetal outcome.

Materials and Methods: Pregnant women ≥32 weeks of gestation. Study population included 3 groups, 31 normotensive pregnant (NP) women as controls, 30 pregnant women with gestational hypertension (GH) and 30 with PE.

Result: Serum uric acid and creatinine levels were significantly elevated in PE (6.261.19 and 0.940.26 mg/dL) when compared with PIH (4.27 1.0 and 0.66 0.19 mg/dL) and NP (4.25 0.8 and 0.63 0.13 mg/dL) (P-value

Key words: Uric acid, creatinine, preeclampsia, gestational hypertension

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