Abstract

Background: Type 2 diabetes mellitus (T2DM) is a common and prevalent metabolic disorder linked to numerous health complications. Recent research has indicated a potential association between T2DM and cognitive impairment, although the underlying mechanisms remain unclear.

Aims and Objectives: This cross-sectional study aimed to investigate neurocognitive functions and information processing ability in T2DM patients compared to healthy individuals.

Materials and Methods: A total of 160 participants, including 80 T2DM patients under medication and 80 age- and sex-matched healthy controls, were enrolled. Cognitive assessments were conducted using Addenbrooke’s cognitive examination (ACE-III) and audiovisual reaction time tests. Statistical analyses were performed to assess differences and correlations between groups.

Results: The study revealed that T2DM patients exhibited delayed neurocognitive functions, including prolonged auditory and visual reaction times, and lower ACE-III scores compared to healthy controls. Notably, a significant positive correlation between HbA1c levels and cognitive impairment was observed in the diabetic group.

Conclusion: This study underscores the presence of cognitive deficits in T2DM patients and highlights the importance of routine cognitive assessment during clinical follow-up. The findings suggest that optimizing glycemic control may offer potential benefits in mitigating cognitive decline in individuals with T2DM. These insights contribute to our understanding of the interplay between T2DM and cognitive function, paving the way for improved patient care and interventions.

Key words: Type 2 Diabetes Mellitus; Neurocognitive Functions; Audiovisual Reaction Times; Addenbrooke’s Cognitive Examination-III