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Original Article

J App Pharm Sci. 2015; 5(5): 013-017

Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

Santosh D. Deosarkar, Rajendrakumar T. Sawale, Tukaram M. Kalyankar.


In view of pharmaceutical applications, the density () and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (v) were calculated from density data and fitted to the Masson relation to determine partial molar volume (v) of drug. Overall, strong drug-solvent interactions with significant structural changes in pure and mixed solvents have been conformed.

Key words: Density, Refractive index, Drug, Partial molar volume

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