Home|Journals|Articles by Year|Audio Abstracts RSS - TOC
 

Original Article

J App Pharm Sci. 2015; 5(5): 013-017


Investigation of Volumetric and Optical Properties of Anti-Emetic Metoclopramide Hydrochloride Drug in Aqueous-Dimethylsulfoxide (DMSO) Solutions At 303.15 K

Santosh D. Deosarkar, Rajendrakumar T. Sawale, Tukaram M. Kalyankar.




Abstract

In view of pharmaceutical applications, the density () and refractive index (nD) of antiemetic metoclopramide hydrochloride monohydrate (MHM) drug in aqueous, aqueous-DMSO and DMSO solutions were measured at 303.15 K in the wide range of concentration of drug. Apparent molar volumes (v) were calculated from density data and fitted to the Masson relation to determine partial molar volume (v) of drug. Overall, strong drug-solvent interactions with significant structural changes in pure and mixed solvents have been conformed.

Key words: Density, Refractive index, Drug, Partial molar volume






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net




eJManager.com
Review(er)s Central
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.