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Effect of a methanol extract of Allium cepa Linn. on incisional wound healing in alloxan-induced diabetic mice

David Emery Tsala, Mendimi Nkodo Joseph, Tatsimo Simplice, Nnanga Nga, Edmond Jacques, Miaffo David.

Abstract
Aim: The objective of the present study was to evaluate the wound healing effect of a methanol extract of Allium cepa Linn. in vivo. Materials and Methods: The healing activity was studied using incision wound on diabetes suppressed wound healing rodent model. Results: Data recorded exhibited a significant improvement of the blood glucose level and scare breaking strength in diabetic mice at 300 and 400 mg/kg onion extract. Histological examination of the general morphology of wounds of extract treated group has shown a normal histological pattern of healthy skin at the same doses. Conclusion: This study illustrated an excellent potential of the onion consumption on dermal wound healing in diabetic patients, with a tentative mechanism of action related to tensile strength improvement and anti-hyperglycemic effect.

Key words: Allium cepa, diabetes, tensile strength


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