Objective: This cross-sectional observational study was carried out to assess and compare the degree of hypovitaminosis D in diabetic and non-diabetic patients of coronary artery disease in Pakistani population.
Methodology: A total of 149 patients of coronary artery disease were selected in this study. These included 77 male and 72 female patients. There were 75 diabetic and 74 were non-diabetic patients. These participants were assessed for their individual serum vit D levels(ng/ml).Diabetic patients were also questioned about their treatment modalities.
Results: The serum levels of vit D betveen diabetic and non- diabetic patients were 16.4(±9.7) ng/ml and 17.4(±7.9)ng/ml but the difference was statistically insignificant (p- value 0.4).However vitamin D levels were significantly lower in patients with family history of coronary artery disease (p- value 0.04).
Conclusion:Results of this study did not substantiate the findings of other studies neither any correlation between vit D levels and glucose homeostasis could be investigated.Diabetes mellitus being a multifactorial disease,vitamin D could be a mediator of metabolic disturbances responsible for long-term health outcomes.
Key words: Vit D,VDR,T1DM,T2DM,,Hypovitaminosis D,Islet Î² cells,Insulin secretion, Insulin sensitivity.
Vit D,VDR,T1DM,T2DM,,Hypovitaminosis D,Islet Î² cells,Insulin secretion, Insulin sensitivity.