Abstract

The aim of this study was to identify antibiotic resistance phenotypes of Staphylococcus aureus isolated from wound infection in orthopedic ward, Federal Medical Center, Birnin Kebbi, Nigeria. Thirty (30) presumptive Staphylococcal isolates that were isolated and processed from wound samples by the laboratory scientist from orthopedic wards, Federal Medical Center, Birnin Kebbi were collected. They were further authenticated by standard microbiological procedure by subjecting them into MSA, gram staining, catalase and coagulase test. Antibiotic susceptibility testing of the S. aureus was carried out using Kirby Bauer disc diffusion methods. A 66.6 % of the S. aureus isolates were obtained from the 30 presumptive Staphylococcal isolates. The isolates exhibited high rates of resistance to Fusidic acid (100%), Erythromycin (65%), Tigecycline (60%) and low resistance to Linezolid (40%) and Gentamicin (35%). Then, 75% of the S. aureus isolates were multidrug resistant. A high proportion of the studied Staphylococcus aureus isolates were resistant to the antibiotics used in this study especially Fusidic acid. Based on these findings, there is a need for prompt antibiotic stewardship and preventive strategies to limit the spread of antibiotic resistant isolates in both clinical and community settings.
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Key words: Staphylococcus aureus, antibiotic resistance phenotypes, multidrug resistance, Wound infection, Federal medical center