Background: A psychological state that causes an individual to behave dysfunctionally at work is known as work stress, which occurs when persons fail to strike a balance between job demands and their abilities to cope with it early. Biochemical changes positively correlate with the level of global job strain and some of its components (interpersonal relations, workhome balance, managerial role, and organization climate).
Objective: To evaluate early biochemical and atherosclerotic changes among Saudi managers and employees exposed to work stresses during their administrative working conditions in the University of Dammam.
Material and Methods: Blood samples were taken from managerial staff and employees (men and women) in the University of Dammam. Biochemical indicators such as lipid profile and different inflammatoryimmunological factors such as preindicators of atherosclerosis of work stress were measured using calibrated equipment.
Result: The results of this study revealed a significant association between managerial duties and job stress in both men and women and control group .This was evidenced in some biochemical parameters such as lipid profile and in different inflammatory and immunological factors. Some confounding factors such as working conditions, training, work planning conditions, and motivations also affected the results.
Conclusion: From this study, we can conclude that early biochemical indicators of atherosclerosis and different inflammatoryimmunological factors should be considered, especially when work stress is expected to reach hazardous conditions. Training and motivation are also the main requirements for release and reduction of work stress.
Key words: Work stress, biochemical changes, atherosclerosis markers, job demands, Dammam University
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