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Arterial stiffness and inflammation in patients on hemodialysis

Vaia D. Raikou, Despina Kyriaki, John N. Boletis.


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Abstract
Objective: Arterial stiffness and inflammation may contribute to enhanced cardiovascular mortality of dialyzed patients.Our aim was the examination of the association between inflammatory factors, arterial stiffening and cardiovascular complications in patients on permanent hemodialysis modalities.
Methods: We studied 76 dialyzed patients, 47 males and 29 females.Patients were separated as regular haemodialysis (HD, n=34) and predilution haemodiafiltration (HDF, n=42) according to treatment modalities.Cardiovascular disease was defined by coronary disease (CD) and peripheral vascular disease (PVD).Arterial stiffness was measured as carotid-femoral pulse wave velocity (c-f PWV) and pulse pressure (PP) was derived.Beta2-microglobulin (beta2M), insulin, leptin, i-PTH concentrations were measured using immunoradioassay.Monocyte chemoattractant protein-1 (MCP-1) and hsCRP were measured by ELISA.Serum bicarbonate concentrations were measured using a blood gas analyzer and the ratio of cholesterol / HDL were calculated.
Results: The patients with CD and the patients with PVD presented significantly higher PP and c-fPWV, than those without CD or PVD.We observed significantly positive association between c-fPWV, PP, age and hsCRP (p

Key words: pulse wave velocity; hsCRP; coronary disease; peripheral vascular disease



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