Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

J App Pharm Sci. 2015; 5(5): 089-093

Inhibition of alpha-amylase by 'insulin plant' (Myrcia sphaerocarpa DC) extracts: an alternative for the treatment of diabetes mellitus?

Angélica Rosa de Oliveira, Chrystian Araújo Pereira.

Diabetes mellitus is an important medical-economical-social problem requiring up search for less costly alternatives for treatment, such as use of medicinal plants. Of the species cited in ethnobotanical studies, the "insulin plant" (Myrcia sphaerocarpa DC) appears among those used by diabetics. The objective of this work was to evaluate the inhibitory activity of alpha-amylase by aqueous extracts of "insulin plant", prepared by different methods at a proportion of 1:200 (w:v), for information about the alleged hypoglycemic effect. For this, five samples of commercially teas "insulin plant" were obtained; aqueous extracts were prepared; and thereafter, they were tested for inhibition of alpha-amylase, before and after exposure to simulated gastric fluid. Results demonstrated before exposure to gastric fluid, a significant inhibition of enzyme activity (greater than 50%) in the samples A and C, using the decoction and sample E in all methods of extraction. Comparing methods of extraction, the decoction was more effective. After exposure to gastric fluid, there was a reduction in the activity of enzyme inhibition, suggesting negative influence of low pH on the properties of the inhibitor. These results do not elucidate the mechanism of the hypoglycemic action reported in folk medicine and literature, but indicate a promising path.

Key words: diabetes; insulin plant; alpha-amylase.

Full-text options

Full-text Article

Journal of Contemporary Medical Education


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.