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Clinical significance of OXA-10-type ESBL producing MDR Pseudomonas aeruginosa

Seniha Senbayrak, Fetiye Kolayli, Asuman Inan, Gulden Topcu Albayrak, Sebahat Aksaray, Haluk Vahaboglu.

Abstract
This study aimed to analyze the clinical significance of OXA-10-type ESBL producing P. aeruginosa in hospital setting. The study was conducted during 2006 and 2007 in the ICU of a teaching hospital with 725 beds. OXA-10-type ESBLs were screened by PCR and sequencing while the expression of the enzyme was verified by isoelectric focusing. Clinical data were obtained from the database of records. A total of 59 P. aeruginosa were identified as the cause of nosocomial infections during the study period. Of these 15 were producing OXA-14, which is a well defined ESBL variant of OXA-10. Among these 15 patients 10 were died. Most infections were ventilator-associated pneumonia (11/15). However, neither co-morbidities nor infection types seems to be strongly related to the adverse outcome in this cohort. All these adverse outcomes were attributed to ESBL producing P. aeruginosa infection. This study suggested that OXA-10 type ESBL variants appear sporadically among P. aeruginosa isolates in hospital settings and cause significant infections in terms of outcome.

Key words: P.aeruginosa, extended-spectrum beta-lactamases, hospital-infection



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