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Original Article

J App Pharm Sci. 2015; 5(5): 028-032


Formulation and Evaluation of Ketoconazole Polymeric Films for Topical Application

Mohamed Salama, Mahmoud A. Mahdy, Amina Mohamed, Aref T. Mohamed, Eseldin I. Keleb, Assad A. Omar, Nagib A. Elmarzugi.

Abstract
The objective of the current paper was to prepare and evaluate various polymeric films for fungal infection treatment and its impact on volunteer patients. Different Eudragit polymeric films containing Ketoconazole as antifungal drug were prepared by solvent casting technique. The prepared films were tested for their physico-mechanical properties as tensile strength, physical endurance, elasticity, water vapor permeation and water loss. The release of ketoconazole from the prepared medicated films was examined. It is involved 20 volunteers suffering from legs fungal infection. Ten of the patients used the films and a follow up study was carried out for 14 days, in comparison with other patients who applied ketoconazole medicated ointment, cream gel and Emulgel. The results revealed that films prepared with Eudragit RL 100 containing glyceryl triacetate produced maximum release of ketoconazole both in vitro and in vivo as compared with other topical dosage forms as ointment, cream, gel and Emulgel. Moreover, the films constitute a simple and convenient method for treatment of various fungal infections. As conclusion, the use of antifungal drugs such as Ketoconazole incorporated in polymeric films, the output results provided promised evidence in the treatment of dermatophytosis.

Key words: Ketoconazole, Eudragit RL 100, Polymeric film, Antifungal drugs



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