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J. Islam. Int. Med. Coll.. 2013; 8(1): 54-59

Comparison of Topical Glyceryl Trinitrate and Nifedipine in Management of Chronic Anal Fissure

Maliha Yunus, Mumtaz Akhtar, Zeeshan Ghani.

Objective: To compare the complete healing of chronic anal fissure by using 2% nifedipine paste and 0.5% glyceryl trinitrate ointment each applied locally for 6 weeks.
Study Design: Randomized Controlled Trail.
Place and Duration of Study: Surgical Unit-I, Pakistan Railway Hospital Rawalpindi spanning over a period of 06 months starting from March 2011 to August 2011.
Materials and Methods: Seventy six patients of chronic anal fissure were included in the study. Non-probability convenience sampling was used for the enrolment of patients. Patients were divided equally into two treatment groups A & B. Group 'A' was treated with topical 2% nifedipine paste and Group 'B' was treated with 0.5% glyceryl trinirate ointment. Patients were asked to come for the follow up after six weeks to look for symptomatic improvement and healing rate.
Results: All 38 patients included in the study completed the follow up after 06 weeks of treatment in either group. Three patients from Group B experienced intractable headache and were managed by analgesics accordingly but they went on to complete the treatment. None of the patient in group A had any significant side effect causing any adjustment in the treatment. At the end of 06 weeks of treatment, 28 patients in Group A and 25 in Group B showed complete healing of anal fissure. The overall healing rate was 69.75 %( n=76). There was statistically no significant difference at the end of 06 weeks of treatment (p=0.454).
Conclusion: It is concluded that 2% nifedipine paste is as effective as 0.5% GTN ointment in terms of healing of chronic anal fissure.

Key words: Chronic Anal fissure, GTN, Nifedipine.

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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.