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Original Article

J. Islam. Int. Med. Coll.. 2011; 6(2): 29-32

The Effect of Heparin on Anterior Chamber Reaction in Pediatric Cataract Surgery

Yasir Iqbal, Sohail Zia, Aneeq Mirza.


Objective: To find out the effects of heparin added to the irrigating solution on anterior chamber reaction in pediatric cataract surgery.
Study Design:Aquasi experimental study.
Place and Duration of study: This study was conducted in a tertiary eye care hospital from Jan 2008 to July 2010.
Materials and Methods: Twenty eyes of fifteen patients aging 4 years to 10 years with uncomplicated pediatric cataract were selected in the study. All children underwent cataract extraction under general anesthesia and received anterior chamber irrigation with heparin sodium (5 IU/cc) during operation added to the irrigating solution of balanced salt solution (BSS Plus). All patients received standardized postoperative treatment. All patients were followed on the first post operative day, after one week, after one month and were advised follow up
at the 3rd and 6th months and postoperative anterior chamber reaction was documented according to modified Hogan's classification on each visit.
Results: Mild anterior chamber reaction was observed in 10 patients (50%) and moderate anterior reaction was the observed in only (15%) three patients on first follow up. Anterior chamber reaction disappeared on 7 post operative day in all patients. Fibrin formation, anterior and posterior synechia, cyclitic and pupillary membrane formation was not observed in any patient. There was also no intraocular lens deposits or posterior capsular opacification (PCO) in any of the cases after the follow up of 6 months.
Conclusion: Heparin sodium in the irrigating solution is safe, effective, and promising method to prevent early postoperative inflammatory reaction in pediatric cataract surgery.

Key words: Heparin, Cataract, Anterior Chamber Reaction, Anticoagulation, Antiproliferative

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