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Research Article

JCR. 2020; 7(18): 3809-3816


PREVALENCE AND ANTIMICROBIAL RESISTANCE PROPERTIES OF EXTENDED-SPECTRUM BETA LACTAMASES (ESBL) PRODUCING KLEBSIELLA PNEUMONIAE ISOLATED FROM THE CASES OF URINARY TRACT INFECTIONS

Bahareh Tavakoli-Far, Fateme Pourhatami, Mohammad Javad Gharavi.

Abstract
Extended-Spectrum Beta-Lactamase (ESBL) producing Klebsiella pneumoniae strains are one of the most prevalent
cause of Urinary Tract Infections (UTIs). The present research was done to study the prevalence and antibiotic
resistance properties of ESBL and non-ESBL producing K. pneumoniae isolated from UTIs. Five-hundred and one urine samples were collected and cultured. Positive samples were analyzed for presence of ESBL producing strains.
Antibiotic resistance pattern was analyzed using disk diffusion method. Forty-six out of 501 samples (9.18%) were
positive for K. pneumoniae. Prevalence of K. pneumonia in male and female urine specimens were 11.39% and
8.76%, respectively. Older than 40 years old male (13.04%) and female (9.72%) had the highest prevalence of K.
pneumoniae. Prevalence of ESBL and non-ESBL producing strains were 56.52% and 43.47%, respectively. ESBL
producing K. pneumoniae harbored the highest prevalence of resistance against ampicillin (96.15%), gentamicin
(96.15%), cefoxitin (92.30%) and cefalexin (84.61%). Non-ESBL producing strains harbored the highest prevalence
of resistance against tetracycline (80%), gentamicin (75%), ampicillin (65%) and cotrimoxazole (50%). Imipenem
and nitrofurantoin had good activity against both ESBL and non-ESBL producing strains. Further researches are
required to found other epidemiological and molecular aspects of the antibiotic resistance of ESBL and non-ESBL
producing K. pneumoniae strains.

Key words: Extended-Spectrum Beta-Lactamase, Klebsiella pneumoniae, Antibiotic resistance, Urinary tract infections.



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