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J App Pharm Sci. 2015; 5(5): 101-105

Environmental biotoxicity screening of some pyrrole and 1,4-dihydropyridine heterocyclic derivatives

A. Idhayadhulla, Aseer Manilal, Behailu Merdekios, R. Surendra Kumar.

Synthesis of pyrrole 1-3 and 1,4-dihydropyridine derivatives 4-6 were prepared from condensation method and synthesized compounds were screened for environmental biotoxicity such as Brine shrimp cytotoxicity, Ichthyotoxic, Larvicidal and Nematicidial activities. Among the compound 3 and 6 shows that highly toxic (LD50: 8.72 and 12.30 μg/mL) against Brain shrimp cyctotoxic screening and compound 3 and 6 was highly toxicity ( LD50 : 5.01 and 7.75 μg/mL) against Antifeedant screening (ichthyotoxic profile). The compound 3 and 6 was highly active (LD50: 12.88 μg/mL, and 14.79 μg/mL) against Larvicidal activity and compound 3 and 6 was highly active ( LD50 : 8.20 μg/mL, and 7.43 μg/mL) against Nematicidal activity.

Key words: Pyrrole derivative, 1,4-dihydropyridine derivative, Brine shrimp cytotoxicity, Ichthyotoxic screening, Larvicidal activity, Nematicidial activity

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