Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

J App Pharm Sci. 2015; 5(Supplement 1): 039-045


Evaluation of Antioxidant and Antimicrobial potential of Leucas urticaefolia (Lamiaceae)

Veena Dixit, Saba Irshad, Priyanka agnihotri, A. K. Paliwal, Tariq Husain.

Abstract
ABSTRACT
Objectives: The present study was designed to screen phytochemical constituents with antioxidant and antimicrobial activity of 50% EtOH extract of Leucas urticaefolia.
Material and methods: Antimicrobial activity was tested against Staphylococcus epidermidis, Salmonella typhi, Salmonella typhimurium, Candida krusei and Aspergillus fumigatus by disc diffusion method. DPPH free radical scavenging assay and ferric reducing assay were used for the determination of antioxidant activity. Qualitative and quantitave analysis of polyphenoles was performed by HPLC-UV.
Results and conclusions: Remarkable antimicrobial potential was exhibited in concentration dependent mode against S. epidermidis, S. typhi and C. krusei. However, S. typhimurium and A. fumigatus showed resistance at lowest concentrations but higher concentrations were effective in inhibiting both microorganisms. Total phelnolic and flavonoid content were found to be 0.713350.025% and 0.25940.028% respectively. Different concentrations of extract showed dose dependent reducing power and scavenging of DPPH radicals with IC50 149.590.24 μg/mL. A marked correlation was observed between antioxidant and antimicrobial activity of 50% EtOH extract of L. urticaefolia. HPLC analysis showed the presence of important polyphenoles and may be attributed to antimicrobial and antioxidant activity of the extract. The observations provided sufficient evidences that L. urticaefolia might indeed be potential sources of natural bioactive agent, if further investigated.

Key words: Leucas urticaefolia, phenols, flavonoids, Antioxidant, Antimicrobial activity



Share this Article


Advertisement
Journal of Contemporary Medical Education

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.