Home|Journals|Articles by Year

Directory for Medical Articles
 

Open Access

Original Article

J App Pharm Sci. 2015; 5(4): 020-025


Development and Evaluation of Chitosan Based Polymeric Nanoparticles of an Antiulcer Drug Lansoprazole

E. Nagarajan, P. Shanmugasundaram, V. Ravichandiran, A. Vijayalakshmi, B. Senthilnathan, K. Masilamani.

Abstract
Objective: The development of new delivery systems for the controlled release of drugs is one of the most innovative fields of research in pharmaceutical sciences. Nanoparticles specially designed to release the drug in the vicinity of target sites. The aim of this study was to formulate and evaluate the Lansoprazole nanoparticles to improve the therapeutic efficacy of Lansoprazole by loading in nanoparticle drug delivery system.
Materials and Methods: Lansoprazole loaded chitosan nanoparticles (CNP1 to CNP10) were prepared by ionotropic gelation method. The formulated nanoparticles were evaluated for external morphological characters, determination of particle size analysis, zeta potential, drug content, entrapment efficiency and in-vitro release studies.
Results: The drug content for the Lansoprazole loaded chitosan nanoparticles varied from 69.57.2% to 87.91.2%. The entrapment efficiencies were found to be minimum and maximum of 39.32.6% and 85.61.2%, the optimum entrapment efficiency was found to be 85.30.8%, particle size varied from 36012nm to 81462nm, zeta potential values were in positive and increased from 11.21.2mV to 18.70.4mV. In-vitro release of drug follows zero order and showed sustained release behavior for a period of 24 hr.
Conclusion: The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Lansoprazole.

Key words: Lansoprazole, polymeric nanoparticles, chitosan, ionotropic gelation






Similar Articles

Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Journal Finder
Covid-19 Trends and Statistics
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.