Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research



Second-line drug resistance patterns among patients with multidrug-resistant tuberculosis of Gujarat, western India

Sachin M Patel, Mitesh H Patel, Sumeeta T Soni, Mahendra M Vegad.

Abstract
Background: Lack of laboratory diagnostic capacity is a crucial barrier preventing an effective response to early and appropriate case detection and treatment of multidrug-resistant tuberculosis (MDR-TB). To date, limited representative drug resistance data are available from India on second-line drug (SLD) resistance.

Objectives: To study SLD resistance patterns in MDR-TB patients of Gujarat, western India.
Materials and Methods: Antituberculosis drug susceptibility testing of 50 MDR-TB isolates particularly for SLDs, namely p-aminosalicylic acid, ciprofloxacin, amikacin, D-cycloserine, kanamycin, and ethionamide, was conducted on solid Lowenstein–Jensen medium using the 1% proportion sensitivity method.

Results: Of 50 MDR-TB isolates tested, 24 (24/50, 48%) were found to be resistant to one or more SLDs. Of 50 MDR-TB isolates, 18 (18/50, 36%) showed resistance to ethionamide, 13 (13/50, 26%) to D-cycloserine, 11 (11/50, 22%) to ciprofloxacin, 7 (7/50, 14%) to kanamycin, 6 (6/50, 12%) to p-aminosalicylic acid, and 5 (5/50, 10%) to Amikacin.

Conclusion: High levels of SLD resistance were found to be present in this study. There is an urgent need for more control and rational use of the widely available fluoroquinolones and other SLDs outside of the Revised National Tuberculosis Control Programme, by both the public and the private health sectors in India.

Key words: Drug resistance, MDR-TB, second-line drugs


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»The evaluation of the implementation level of nurses working in neonatal intensive care unit in the treatment of neonatal jaundice
»Complementary and alternative medicine use in medical OPD patients of rheumatoid arthritis in a tertiary care hospital
»Relationship between birth order, personality and academic performance
»Deep Iris: Deep Learning for Gender Classification Through Iris Patterns
»Opportunistic screening for diabetes mellitus among adults attending a primary health center in Puducherry
»Brain Death Declaration In Our Hospital
»Assessing severity of involvement of autonomic functions in iron-deficiency anemia patients
»Forensic Conception: DNA typing of FTA Spotted Samples
»Morbidity profile of neonates and biological factors associated with it among admitted newborn babies at tertiary care institute, Jamnagar
»Seroprevalence of hepatitis B virus infections among health care workers at the Bulle Hora Woreda Governmental Health Institutions, Southern Oromia, Ethiopia
»Protective Effect of Some Egyptian Medicinal Plants Against Oxidative Stress in Rats



Advertisement
Journal of Environmental and Occupational Science

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.