The Government of the Riau Islands Province announced the first case of Covid-19 on Tuesday, March 17, 2020. The government is building a Covid-19 Emergency Handling Hospital on Galang Island, Riau Islands, operating on Monday, April 6, 2020. As of July 23, 2020, there are currently no significant additional new cases of Covid-19, 28 patients are still being treated, out of a total of 351 cases, the cure rate in Riau Islands reaches 87.5 percent or 307 cases as a population, with the Slovin Formula sample Becomes174 respondents. The recovery of Covid-19, whether it has to do with spirituality, economic resilience in which Batam, Bintan, Karimun as Special Economic Zone Regions, and health behaviors that are always recommended by the Regional Leadership in the Riau Islands, give rise to immunity so that it influences the pandemic Covid-19. The research model used is a mixed-method, by combining quantitative with SEM software AMOS v.24 and qualitative with interviews with respondents and the community as well as the Covid-19 Kepri Cluster Team. The result is that changes in immunity are influenced by spiritual, economic resistance, healthy behavior by 89.80%, the remaining 10.10% is influenced by other variables not included in this study, changes in Free co-19 pandemics are influenced by spiritual, economic resistance, healthy behavior, and immunity by 100%. This finding proves the truth of the Qur'an: "O people, verily you have come to learn from your Lord and healer for diseases in the chest and guidance and mercy for those who believe. (Surah Yunus: 57) Moreover, "And in the middle of the night you pray and recite as additional worship for you: may your Lord lift you to a place of praise." (Surah Al Israa: 79) The truth of the work system research Tahajud prayers can improve the immune response immune system.
Key words: spiritual, economic resistance, healthy behavior, immunity, free COVID-19 pandemics