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Original Research

JCDR. 2020; 11(4): 200-204

Thyroid Status Effect on Leptin Hormone and Lipid Profile in Female Patients with Thyroid Dysfunction

Adil Abdulrazzaq Waheeb, Taqi Mohammed Jwad Taher, Iqbal Abed Fahad, Firas Turki Rashed Sarray.


Background: Thyroid gland is one of the most important glands in the human body which responsible for the secretion of Thyroxin (T4) and Triiodothyronine (T3) hormones. These hormones in addition to Thyroid Stimulating Hormone (TSH) have a great effect on other hormones like leptin. So, the objective of this study is to assess any correlation between thyroid hormones, lipid profile, and leptin in female patients with thyroid dysfunction.

Methods: This cross-sectional study was conducted for 50 women diagnosed with hypothyroidism (25) and hyperthyroidism(25) attending AL-Karamah Teaching Hospital in Wasit. All of them ranged between 20-55 years. The researchers obtained verbal consent and then took a serum sample from all of them to test the level of thyroid hormones (T4, T3), TSH, leptin hormone and lipid profile (TG, HDL-C, LDL-C and cholesterol) were determined. Data were analyzed by SPSS version 23 using descriptive statistic for quantitative variables. Independent t-test, correlation and regression analysis were also used.

Results: This study found that both the leptin level and lipid profiles (Cholesterol, TG, LDL and HDL) were significantly higher (P

Key words: Hypothyroidism, Hyperthyroidism, Leptin, Lipid Profile, TSH.

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