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Research Article

. 2020; 11(4): 166-173


Cardiovascular Risk Factors and Metabolic and Endocrine Features in Non-hyperandrogenic and Hyperandrogenic PCOS Phenotypes of Malay Women

Hanifullah Khan, Abdul Rashid Abdul Rahman, Fazliana Mansor.

Abstract
Objective: To compare the cardiovascular risk factors and metabolic features between hon-hyperandrogenic and hyperandrogenic Malay women with PCOS.

Design: Cross-sectional clinic based study.

Subjects: 109 Malay women with PCOS based on the Rotterdam criteria divided into non-hyperandrogenic and hyperandrogenic phenotypical groups.

Measurements: Anthropometric, biochemical and endocrinological parameters were compared between the two groups of Malay PCOS women.

Results: Overall, both groups women had very similar metabolic and endocrine characteristics. Cardiovascular risk factors were comparable in both phenotypes of PCOS. Regression analysis indicated that free testosterone and HbA1c were significantly higher in the hyperandrogenic women (p =.002 and p =.021 respectively).

Conclusions: Malay women with non-hyperandrogenic and hyperandrogenic PCOS phenotypes have similar cardiometabolic profile and cardiovascular risk factor prevalences. Therefore, all Malay women with PCOS should be considered as a singular entity with regards to cardiometabolic risk.

Key words: Risk Factors, Metabolic and Endocrine, PCOS Phenotypes.






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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.