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Original Article

J App Pharm Sci. 2015; 5(6): 104-108


Prevention of Peri-Anesthetic Hypothermia by Regulating Cutaneous Micro-Circulation: a Rodent Model

Nachum Nesher, Inna Frolkis, Amir Ganiel, Yanai Ben-Gal, Yosef Paz, Kramer Amir, Dimitri Pevni.

Abstract
Objectives: Patients undergoing surgery involving general anesthesia often suffer from hypothermia, which is associated with various complications. External heating and warming are used to combat hypothermia throughout surgery; however their effectiveness is often limited. In this study we investigated a unique approach utilizing a natural physiological mechanism; protective cutaneous vasoconstriction for reducing peri-anesthetic hypothermia. The concept is based on the dermal application of a cream with vasoconstrictive alpha adrenergic agonist properties designed for this purpose; “thermal cream” (TC). Topical application of the cream was tested in a rodent model. The aim of the present study was to test the efficacy of a topical vasoconstrictive application in reducing peri-anesthetic hypothermia.
Materials and Methods: Adult Wistar rats were divided into two experimental arms: application of thermal cream was compared to application of a base cream without any active compound (control) under the same conditions. The rats were exposed to an ambient temperature of 21ºC. Their skin and core temperatures were measured and compared before, during and after anesthesia.
Results: The rats underwent rapid hypothermia immediately after the induction of anesthesia. The rats treated with thermal cream had a significantly higher core body temperature than the controls throughout the entire anesthetic period. This difference was even greater when the cream had been applied before the animal underwent anesthesia.
Conclusions: The thermal cream was effective in attenuating peri-anesthetic-induced hypothermia in a rodent model. It was easy to apply with no immediate mortality or other major adverse events.

Key words: per-anesthetic hypothermia prevention surgerical



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