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Potential Role of Oxidized LDL (ox-LDL) and Adhesion Molecules (VCAM-1, ICAM-1) in Type 2 Diabetes Mellitus Patients in Qassim region, KSA

Manal Basyouni, Maha Ahmed, Hisham Ismail, Iman Esmat.

Background: Type-2 diabetes mellitus (type 2 DM) is powerful and independent risk factors for coronary artery disease, stroke, and peripheral arterial disease. Accelerated atherosclerosis is the major vascular complication of diabetes, constituting the main cause of morbidity and mortality in this common metabolic disorder. The role of oxidized low density lipoprotein (Ox-LDL) and cell adhesion molecules (CAMs) in diabetic complications as atherogenesis is unclear and available studies are contradictory.
Objectives: The current study was conducted to investigate the pathological role of oxLDL and cell adhesion molecules (VCAM-1 and ICAM-1) and their clinical impact in type 2 DM patients.
Patients and Methods: The serum levels of ox-LDL and VCAM-1 and ICAM-1 were measured by enzyme-linked immunosorbent assay. Their levels were correlated to glycemic status and lipid profile in 60 type 2 diabetic patients compared to 25 healthy subjects.
Results: The current study revealed a significant higher ox-LDL and VCAM-1 levels in diabetic patients compared to healthy group, with significant higher levels of oxLDL in uncontrolled diabetes compared to controlled diabetes. The elevation of ox-LDL in DM patients (p

Key words: Type 2 Diabetes Mellitus, Oxidized LDL, Intercellular adhesion molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1)

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