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Rectal insufflation of ozone attenuates chronic oxidative stress in elderly patients with cardiovascular diseases

Irina Wilkins-Perez, Livan Delgado-Roche, Juan M. Barrios, Gloria B. Fabregas-Popoco.


Objective: Aging is a biological inevitable process, characterized by a progressive deterioration of physiological functions and metabolism, ultimately leading to death, meanwhile cardiovascular diseases are the most common cause of death in aged subjects. Chronic oxidative stress contributes to age-associated cardiovascular dysfunctions and diseases. Because ozone therapy can modulate the antioxidant system the aim of this study was to investigate the therapeutic efficacy of ozone in aged patients with cardiovascular diseases.
Methods: A randomized controlled clinical trial was performed with 30 patients older than 60 years with a diagnosis of any cardiovascular disease. A parallel group (n = 40) age and gender matched was used as reference for the determined variables. Patients were treated with 200 ml ozone/oxygen mixture at 20 µg/mL of ozone by rectal insufflation once a day during 15 days.
Results: Ozone improved the antioxidant status of patients by reducing biomarkers of protein and lipid oxidation and regulating the oxidant/prooxidant balance.
Conclusion: Medical ozone treatment could be used to ameliorate the redox disruption in aged patients and as a complementary therapy in the treatment of cardiovascular diseases and its complications.

Key words: Aging, cardiovascular diseases, medical ozone, rectal insufflation

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