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Original Research

RMJ. 2015; 40(2): 207-209

Molecular characterization of Prothrombin G20210A gene mutations in pregnant Sudanese women with spontaneous recurrent abortions

Asaad Mohammed Ahmed Abd Allah Babker, Fath Elrahman Mahdi Hassan Gameel.


Objective: This study aimed at analyzing the association between recurrent spontaneous abortion and prothrombin G20210 gene mutation in Sudanese women.
Methodology: This prospective analytical case control study was carried out at Omdurman Maternity Hospital, Sudan and included 100 Sudanese women who experienced three or more of the adverse pregnancy outcomes during their reproductive age. 96 controls were also included. Cases and controls were tested for the above mutations.
Results: Out of 100 case, 3 (3%) had gene mutation and none was found control group (P =0.091).
Conclusion: We found limited importance of prothrombin mutation as genetic risk factor among women with recurrent spontaneous abortion. There was no significant association between cases carriage any of this mutation and risk with recurrent pregnancy miscarriage.

Key words: Factor prothrombin, mutation, Sudanese pregnant women, recurrent miscarriage

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