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Original Research

RMJ. 2012; 37(4): 344-347


Effect of age and gender on blood lipids and glucose

Sikandar Hayat Khan, Umair Masood, Muhammad Shahzad Hanif, Syed Owen Raza Shah Bokhari, Muhammad Junaid Khan.

Abstract
Objective-
1-To correlate age with fasting plasma glucose, triglycerides and total cholesterol
2-To compare fasting blood glucose levels among different quartiles of age
3-To compare the effect of gender on lipids and fasting blood glucose
Methods-
This cross-sectional study was carried out between May-2010 to April-2011 at the department of pathology & medicine, PNS RAHAT. Target population were adult subjects who visited the lab in exact medical fasting status for measurement of blood glucose to rule out diabetes mellitus. Based upon non-probability convenience sampling a total of 516 subjects were finally included in the study and sampled for fasting blood glucose, total cholesterol, and triglycerides. The results were grouped as: Fasting blood glucose: [(Normal Glucose Tolerance=NGT < 5.6 mmol/L), (Impaired Fasting Glucose=IFG (5.6 to 6.9 mmol/L) (Newly Diagnosed Diabetes Mellitus=NDDM > 6.9 mmol/L)], Serum triglycerides:[ (Group-1 < 1.7 mmol/L), (Group-2:1.7 to 2.29 mmol/L), (Group-3: 2.30 – 4.0 mmol/L) and (Group-4: > 4.0 mmol/L)], [Total cholesterol:(Group-1 < 5.2 mmol/L), (Group-2:5.2-6.2 mmol/L), and (Group-3: > 6.2 mmol/L)] and different age groups were made to compare the occurrence of different categories of glycemia and lipidemias.
Results-
The mean differences for fasting blood glucose across age groups were observed to rise from 21-30 years age group [5.01 (95% CI: 4.77-5.25) mmol/L] to higher levels [6.25 (95% CI: 5.63-6.87) mmol/L] in people having ages between 50-60 years; however, later in life the mean fasting blood glucose were observed to be lower. [P < 0.001].The lipids including total cholesterol and triglycerides rose till the 5th decade of life, and then settled/fall from ensuing 6th decade. Percentage wise most cases of diabetes mellitus were observed between ages 41-50 years. Gender differences were not significant between groups based upon glycemia and lipidemia.
Conclusion-
Fasting glycemia and lipidemia were observed to show significant differences among different age groups.

Key words: Fasting plasma glucose, diabetes mellitus, total cholesterol, triglycerides, age



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