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RMJ. 2012; 37(4): 344-347

Effect of age and gender on blood lipids and glucose

Sikandar Hayat Khan, Umair Masood, Muhammad Shahzad Hanif, Syed Owen Raza Shah Bokhari, Muhammad Junaid Khan.

1-To correlate age with fasting plasma glucose, triglycerides and total cholesterol
2-To compare fasting blood glucose levels among different quartiles of age
3-To compare the effect of gender on lipids and fasting blood glucose
This cross-sectional study was carried out between May-2010 to April-2011 at the department of pathology & medicine, PNS RAHAT. Target population were adult subjects who visited the lab in exact medical fasting status for measurement of blood glucose to rule out diabetes mellitus. Based upon non-probability convenience sampling a total of 516 subjects were finally included in the study and sampled for fasting blood glucose, total cholesterol, and triglycerides. The results were grouped as: Fasting blood glucose: [(Normal Glucose Tolerance=NGT < 5.6 mmol/L), (Impaired Fasting Glucose=IFG (5.6 to 6.9 mmol/L) (Newly Diagnosed Diabetes Mellitus=NDDM > 6.9 mmol/L)], Serum triglycerides:[ (Group-1 < 1.7 mmol/L), (Group-2:1.7 to 2.29 mmol/L), (Group-3: 2.30 – 4.0 mmol/L) and (Group-4: > 4.0 mmol/L)], [Total cholesterol:(Group-1 < 5.2 mmol/L), (Group-2:5.2-6.2 mmol/L), and (Group-3: > 6.2 mmol/L)] and different age groups were made to compare the occurrence of different categories of glycemia and lipidemias.
The mean differences for fasting blood glucose across age groups were observed to rise from 21-30 years age group [5.01 (95% CI: 4.77-5.25) mmol/L] to higher levels [6.25 (95% CI: 5.63-6.87) mmol/L] in people having ages between 50-60 years; however, later in life the mean fasting blood glucose were observed to be lower. [P < 0.001].The lipids including total cholesterol and triglycerides rose till the 5th decade of life, and then settled/fall from ensuing 6th decade. Percentage wise most cases of diabetes mellitus were observed between ages 41-50 years. Gender differences were not significant between groups based upon glycemia and lipidemia.
Fasting glycemia and lipidemia were observed to show significant differences among different age groups.

Key words: Fasting plasma glucose, diabetes mellitus, total cholesterol, triglycerides, age

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