Ficus platyphylla Del. Holl (Moraceae) and Ximenia americana L. (Olacaceae) are medicinal plants used in the treatment of several diseases. This study was designed to investigate their effects on some markers of hepatotoxicity in albino rats. Twenty-four (24) adult Wistar rats of both sexes were divided into 4 groups of 6 rats each. Group 1, 2, 3 and 4 were treated with distilled water, F. platyphylla, X. americana and a mixture of F. platyphylla and X. americana extracts respectively in a ratio 1:1 weight by weight. A dose of 250 mg/kg body weight was administered orally daily for 21 days, after which blood samples were collected in a clean container and centrifuged for 10 minutes at 3000rpm. The serum was obtained and used for biochemical analysis. Markers of hepatocellular injury specifically, ALT, AST, Albumin, T. bilirubin and T. Protein, were assayed accordingly. The activity of ALT showed no significant (p>0.05) difference in group 4 with the control. In AST, there is a significant difference (p
Key words: Ficus platyphylla, Ximenia americana, hepatocellular injury, medicinal plants
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