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Disulfiram Neurotoxicity: Decrements in Ethanolamine, Serine, and Inositol Glycerophospholipids.

Paul L Wood, Ryan S Alexander, Cameron C Felty.

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Aim: Disulfiram has rare serious neurotoxicities including optic neuropathy, peripheral neuropathy and basal ganglia lesions. Since the mechanism of these toxicities is not understood, we undertook a lipidomics analysis of the effects of disulfiram on human lymphoblasts. Materials and Methods: Human lymphoblasts were incubated with disulfiram and the cellular lipidome was analyzed by ESI-high resolution mass spectrometry. Results: Disulfiram decreased the levels of a large number of glycerophospholipids, sphingolipids, and diacylglycerols. Conclusion: Disulfiram has dramatic effects on the levels of structural lipids in human lymphoblasts. These actions may explain the neurotoxicities of this drug in humans.

Key words: disulfiram, neurotoxicity, lipidomics, lymphoblasts

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