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Original Article

J App Pharm Sci. 2014; 4(12): 090-094

Alteration in Levels of Minerals in DEN induced Hepatocellular carcinoma in Wistar Albino Rats

B. Arirudran, Vijayalakshmi Krishnamurthy, A. Saraswathy.


Many of infectious diseases are known to be treated with herbal remedies throughout the history of mankind: even today plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. The discovery of medicinal plants in different parts of the world is important for agriculture and medical sector. The total protein, albumin, globulin and A/G ratio were significantly decreased in DEN induced HCC animals. After administration of ethanolic extract of R.tuberosa the level of total protein, albumin, globulin and A/G ratio levels were back to normal. The level of magnesium, sodium and potassium were significantly decreased but the level of calcium was significantly increased in DEN induced HCC animals. These changes were reverted to near normal with treatment of ethanolic extract of R.tuberosa and thereby liver cirrhosis was reduced along with immune system being protected. In conclusion, results of the present study suggest that DEN-induced hepaticcarcinogesis play certain role in mineral disturbances. Low levels of albumin and related ascites may be one of the major causes of the imbalance of mineral metabolism in liver diseases. Over all the present study gives scientific evidence for a new novel innovative chemotherapeutic agent for management of human hepato carcinoma to balance the mineral metabolism in hepatocarcinoma. However further studies are needed to isolate the active compounds from the ethanolic extract of R.tuberosa to confirm these properties for safe, efficacious, cost effective and eco-friendly anticancer drug.

Key words: KEY WORDS: Ruellia tuberosa, doxorubicin, N-Nitrosodiethylamine, hepatocellular carcinoma.

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