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Protective effect of quercetin on weight drop injury model-induced neuroinflammation alterations in brain of mice

Hmangte Hitler Kom,Mesram Nageshwar,Kota Srilatha,Karnati Pratap Reddy.

The neuroinflammatory response following traumatic brain injury is known to be a key secondary injury factor that can play a critical role in accelerating the progression of neurodegeneration. This study reports protective effect of dietary quercetin against neuroinflammation induced changes in mice triggered by weight drop injury model. Quercetin is a natural flavonoid found in high quantities in fruits and vegetables, with properties of antioxidant, free radical scavenger and anti-inflammation. Hence, this study reports the effects of quercetin on neuroinflammation mediated oxidative stress, behavioural and histological alterations in mice. Mice were divided into four groups: control, inflammation, inflammation+Quercetin (20mg/kg mass) and Quercetin (20mg/kg mass). The treatments were carried out on mice for 7 days and subsequently behavioural studies were conducted and then brains were collected, used for biochemical and histological studies. Mice undergoing inflammation showed significant (p

Key words: Quercetin, Weight drop injury, Neuroinflammation, Oxidative stress, Histological alteration.

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