The neuroinflammatory response following traumatic brain injury is known to be a key secondary injury factor that can play a critical role in accelerating the progression of neurodegeneration. This study reports protective effect of dietary quercetin against neuroinflammation induced changes in mice triggered by weight drop injury model. Quercetin is a natural flavonoid found in high quantities in fruits and vegetables, with properties of antioxidant, free radical scavenger and anti-inflammation. Hence, this study reports the effects of quercetin on neuroinflammation mediated oxidative stress, behavioural and histological alterations in mice. Mice were divided into four groups: control, inflammation, inflammation+Quercetin (20mg/kg mass) and Quercetin (20mg/kg mass). The treatments were carried out on mice for 7 days and subsequently behavioural studies were conducted and then brains were collected, used for biochemical and histological studies. Mice undergoing inflammation showed significant (p
Quercetin, Weight drop injury, Neuroinflammation, Oxidative stress, Histological alteration.