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Original Article

J App Pharm Sci. 2014; 4(12): 060-064


Stability Indicating Method for the Determination of Mefenamic Acid in Pharmaceutical Formulations by HPLC

Bhagyashree R. Dhumal, Kishore P. Bhusari, Madhukar R. Tajne, Mahavir H. Ghante, Nishant S. Jain.

Abstract
A simple, RP-HPLC stability indicating method was developed for determination of mefenamic acid in pharmaceutical formulations and its degradation products using C8 column with the mobile phase containing mixture of Buffer : Acetonitrile + THF in the ratio of 55:45 v/v at a flow rate of 1.0 ml/min was found to yield satisfactory retention time of about 18.253 min with sharp symmetrical peak at a detection wavelength of 285 nm. The method was validated using ICH guidelines and was found to be linear in the range 0.5-2 µg/ mL. The proposed method shows good separation of mefenamic acid and its degradation products. The developed method can be applied successfully for the determination of mefenamic acid and its degraded products.
Keywords: HPLC, Mefenamic acid, Stress degradation.

Key words: Keywords: HPLC, Mefenamic acid, Stress degradation.



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