Abstract

This study explores a novel approach to treat acne using silver nanoparticles (AgNPs) synthesized from Plantago major (Pm). We aimed to create a stable, safe, and effective anti-acne sheet mask. AgNPs were synthesized using water extracts of Pm leaves and formulated into an anti-acne sheet mask. The sheet mask was assessed for physical stability through freeze-thaw cycling tests and evaluated for safety through dermal irritation tests. The efficacy was assessed on the sheet mask’s impact on Propionibacterium acnes bacteria and inflammation. The anti-acne sheet mask containing AgNPs synthesized from Pm was found to be physically stable and safe for use, with no significant skin irritation observed. The formulation exhibited effective inhibition of P. acnes, particularly in the formula containing only AgNPs. In addition, the sheet mask preparations demonstrated substantial anti-inflammatory activity. The anti-acne sheet mask containing AgNPs synthesized from Pm exhibited favorable safety profile, inhibited P. acnes bacteria, and possessed anti-inflammatory properties.

Key words: anti-acne, sheet mask, silver nanoparticles, Plantago major, safety, efficacy