Home|Journals|Articles by Year|Audio Abstracts
 

Original Research



Role of fumaric acid in anti-inflammatory and analgesic activities of a Fumaria indica extracts

Anshul Shakya, Gireesh Kumar Singh, Shyam Sunder Chatterjee, Vikas Kumar.




Abstract

Aim: To test whether the ethanolic extract of Fumaria indica (FI) possesses anti-inflammatory and analgesic activities, and fumaric acid (FA) could be one of its bioactive constituent involved in such activities of the extract.
Methods: For anti-inflammatory activity, carrageenan induced edema and cotton pellet induced granuloma tests in rats and for analgesic activity rat tail flick test, and hot plate and acetic acid writhing tests in mice were used. All tests were performed after seven daily oral doses of the Fumaria indica extract (100, 200 and 400 mg/kg/day) and pure fumaric acid (1.25, 2.50 and 5.00 mg/kg/day).
Results: Anti-inflammatory activities of FI and FA were observed in carrageenan induced edema and cotton pallet granuloma even after their lowest tested doses. No analgesic activity of lowest tested dose of FA was observed in the acetic acid writhing test, but likewise all tested dose levels of FI, higher tested dose levels of FA were also possess significant analgesic activity in this test. Further, significant analgesic activities of both FI and FA in hot plate and tale flick tests were observed after all their tested doses.
Conclusions: These observations are in agreement with our working hypothesis on the connection of FA in mode(s) of action(s) of FI, and reaffirm the conviction that FI could be an herbal alternative against fibromyalgia and other pathologies often associate with, or caused by, inflammatory processes.

Key words: Fumaria indica, Fumaric acid, Analgesic, anti-inflammatory, Central sensitivity syndrome; CNS function.






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.