Home|Journals|Articles by Year

Directory for Medical Articles

Original Research

RMJ. 2015; 40(1): 52-58

Histopathological spectrum of breast diseases in a multi-ethnic population of Karachi, Pakistan

Bushra Sikandar, Muhammad Asif Qureshi, Lubna Avesi, Naila Sheraz, Talat Mirza.


Objective: To generate national level statistics to calculate the disease burden and to implement awareness and screening programs for breast cancer.
Methodology: All breast biopsies received at the Dow Diagnostic Research and Reference laboratory (DDRRL) during 2008-2012 were included in the analyze the spectrum with implementation of latest intrinsic molecular sub-typing.
Results: Out of 2740 cases, 1493 (54.50%) were diagnosed as benign and 1247 (45.40%) as malignant lesions. Most frequent lesion in male was gynecomastia. However, in females, most common benign lesion was fibroadenoma with a frequency of 745 (27.91%), while invasive ductal carcinoma II was the most common malignant lesions observed in 584 (21.88%) cases. Mean age of patients with benign lesion was 30 years and malignant lesion was 45 years. Selected cases (n=460) were stained for ER, PgR and Her-2 expression. Of these, ER expression was found in 208 (44.30%) biopsies, PgR was found to be positive in 183 (38.90%) and Her-2 was positive in 44 (47.20%) biopsies. Intrinsic molecular sub-typing showed that 36% tumors were basal like, 28% were Lumial A, 18% were Luminal B Her-2 positive, 2% were Luminal B Her-2 negative and 16% were Her-2 positive.
Conclusion: Our study delineates interesting facts including increased magnitude of breast cancer prevalence in our setup (2008-2012). We represent four years data to demonstrate breast diseases specturm in the largest diagnostic and refernece laboratory of Sindh.

Key words: Breast diseases, breast cancer, DDRRL, Karachi

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.