Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

Vitamin C pretreatment mitigates the genotoxic effects of sodium arsenite in human lymphocytes in vitro

Prasenjit Roy, Sarbani Giri, Anita Mukherjee.

The present study was aimed to evaluate Vitamin C (VC) as a potent natural antioxidant to reduce the genotoxic effects of sodium arsenite in human lymphocytes. The study was design to assess the role of VC (10 g/ml), upon sodium arsenite induced in vitro genotoxicity by using alkaline comet assay technique. Lymphocytes were incubated for 3h at 37C in RPMI-1640 medium with different concentrations of sodium arsenite (12.5 g/ml, 25 g/ml, 50 g/ml and 100 g/ml) and also in combined treatment of sodium arsenite with VC (100 g/ml + 10 g/ml).Our findings suggest that treatment with sodium arsenite increased the primary DNA damage and pretreatment with VC reduces the genotoxic effects of sodium arsenite effectively and efficiently at the highest concentration in vitro, proving its mitigating effect.

Key words: Vitamin C, Sodium arsenite, Comet assay, Lymphocyte.

Similar Articles

Simultaneous adsorption for cationic and anionic dyes using chitosan/electrospun sodium alginate nanofiber composite sponges.
Zhao X, Wang X, Lou T
Carbohydrate polymers. 2022; 276(): 118728

Method for Isolating Extracellular Vesicles from Human Neural Stem Cells Expanded Under Neurosphere Culture.
Koopaei NN, Schmittgen TD, Reynolds BA, Azari H
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 87-94

Isolation and Culture of Adult Hippocampal Precursor Cells as Free-Floating Neurospheres.
Rust R, Walker TL
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 33-44

A sensitive electrochemiluminescence biosensor for assay of cancer biomarker (MMP-2) based on NGQDs-Ru@SiO2 luminophore.
Fan X, Wang S, Liu H, Li Z, Sun Q, Wang Y, Fan X
Talanta. 2022; 236(): 122830

Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity.
Ferrari F, Moretti A, Villa RF
Neural regeneration research. 2022; 17(2): 292-299

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites