Assisted Reproductive Technology (ART) has dramatically progressed over the last 30 years. Intracytoplasmic Sperm Injection (ICSI), selection and injection of single spermatozoa into an oocyte is probably the most important development in this field. Here is a case summary of a couple who conceived with ICSI treatment after twelve years of primary sub-fertility. It was done at Australian Concept Infertility Medical Centre, Karachi. The diagnosis of anencephaly was made at 22 weeks of gestation. It is of prime importance that counseling about the spectrum of possible fetal adverse outcome is made an integral part of the care of couples seeking fertility treatment.
ICSI, Anencephaly in Singleton, Counseling